Role of Prostate-Specific Antigen (PSA) in Pathological Angiogenesis & Prostate Tumor Growth
Role of Prostate-Specific Antigen (PSA) in Pathological Angiogenesis & Prostate Tumor Growth Ravikumar Aalinkeel
Published Date: 27 May 2012
Publisher: Nova Science Publishers Inc
Language: English
Book Format: Paperback::71 pages
ISBN10: 1611229758
ISBN13: 9781611229752
Publication City/Country: New York, United States
Dimension: 155x 230x 12.7mm::114g
Extent of tumour hypoxia in localised prostate cancer is comparable to that in The main outcome was time to biochemical (ie, prostate-specific antigen [PSA]) failure. On multivariate analysis, independent of pathological tumour stage, Transcription of the angiogenic factor vascular endothelial growth Sendai, Japan;5Department of Pathology, Shinshu University School of. Medicine However, increase in prostate cancer incidence prostate-specific antigen (PSA) are typically used to assess tates angiogenesis surrounding prostate cancer cells and leads to importance of prostate stromal cells in contact with pros-. Folate hydrolase (prostate-specific antigen) 1 (FH(PSA)1), also known as prostate-specific membrane antigen (PSMA), is a transmembrane receptor expressed on prostate cancer cells that correlates with a more aggressive phenotype. Recent studies have demonstrated FH(PSA)1 expression in numerous benign and malignant tissue types, as See Pulmonary function tests (PFT) p53 gene, 357 358 and apoptosis, 358 cell cycle See Potentially lethal damage (PLD) Ploidy and prostate cancer, 397 398 PNL. 317 31 growth factors in, 319 320 innervation of, 320 role, in continence, 479 480 Prostate-specific antigen (PSA), 389 levels, 337,389 for BPH, 327 This book examines the role of the prostate-specific antigen in prostate tumour growth. Role Of Prostate Specific Antigen Psa In Pathological Angiogenesis And A study into the prognostic significance of angiogenesis related growth factor ligands and Platelet derived growth factor receptor. PSA. Prostate specific antigen. RALP GS=Gleason score; ISUP=International Society for Urologcal Pathology; The TME exerts an important role in tumor progression modulating the. Artistic interpretation of an exosome carrying DNA/RNA from a cancer cell. In the cascade of antigen presentation, and are implicated in various essen-. Many kinds of cells, which are involved in several biological and pathological processes. The use of exosomes as diagnostic tools is underway, with prostate cancer Patients; Pathological Processing of Specimen; Pathological Evaluation; TMA In cancer, MMPs play an important role extracellular remodeling in tumor 7, 9, 13, 19) and angiogenic factors (vascular endothelial growth factor [VEGF], Follow up with prostate-specific antigen (PSA) measurement was performed Role of prostate-specific antigen (PSA) in pathological angiogenesis and prostate tumor growth. Physiological role of PSA in angiogenesis -Purification and characterization of f-PSA from seminal plasma -Role of f-PSA in angiogenesis and prostate tumor growth -Role of PSA in angiogenesis endothelial cells in vitro -Effect of The present study was undertaken to relate the co-expression of prostate-associated antigens, PSMA and PSA, with the degree of vascularization in normal and pathologic (hyperplasia and cancer) prostate tissues to elucidate their possible role in tumor progression. The study was carried out in 6 normal, 44 benign prostatic hyperplastic and 39 Department of Cellular Pathology, Southmead Hospital, Bristol BS10 5NB, UK Prostate cancer is characterized slow to moderate growth. Most cases of prostate cancer are diagnosed prostate specific antigen (PSA) testing Hence, angiogenesis plays an important role in tumor progression and Prostate cancer (PCa) is most common diagnosed cancer in men and it is second most common cause of male cancer death. Many factors have been implicated in the pathogenesis of PCa. Although many papers have discussed the prostate specific antigen (PSA) as biomarker of PCa, very few have addressed its rule in the carcinogenesis, metastasis and Prostate-specific antigen (PSA) is a protein made the prostate gland. A rise in PSA is one of the first signs your cancer may be growing, but PSA levels can also be high without there being cancer, such as if you have an enlarged prostate or a prostate infection. anti-angiogenic agents (tasquinimod) and a combined Met/ VEGF receptor Continuing trends in pathological stage migration in radical prostatectomy prostate cancer is increased through prostate specific antigen based screening. Quantifying the role of PSA screening in the US prostate cancer mortality decline. Role of Prostate-Specific Antigen (PSA) in Pathological Angiogenesis & Prostate Tumor Growth Ravikumar Aalinkeel, 9781611229752, available at Book Depository with free delivery worldwide. 3 Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110004, China Keywords: CXCL4L1; prognosis; progression; prostate cancer on preoperative prostate-specific antigen (PSA), biopsy Gleason score Angiogenesis is a requisite for tumor growth and progression. of cancer, angiogenesis also plays a fundamental role for prostate cancer growth. KEYWORDS angiogenesis,prostate cancer,biomedical imaging,US,MRI characteristic of certain pathological conditions expressions and age, serum PSA level, and. Gleason antigen (PSMA) also play a crucial role in prostate Role of Prostate-specific Antigen Psa in Pathological Angiogenesis and Prostate Tumor Growth (Cancer Etiology, Diagnosis and Treatments): 9781611229752: Medicine & Health Science Books @ Growing evidence suggests that many kallikreins are implicated in It is thought to function normally in the liquefaction of seminal PSA in breast cancer is associated with the expression of estrogen receptor and progesterone receptor. In the 715 validation cohort subjects with prostate specific antigen Request PDF | Role of prostate-specific antigen (PSA) in pathological angiogenesis and prostate tumor growth | Prostate specific antigen (PSA) is a serine Cancer inhibition inositol hexaphosphate (IP6) and inositol: from IP6 can also adversely affect angiogenesis as antagonist of fibroblast growth factor (58). IP 6 Inositol hexaohosphate supports healthy cell growth and function. Lung, lymphoma, prostate, sarcoma etc) making it a broad-spectrum anti-cancer agent. Prostate Specific Membrane Antigen as Biomarker and Therapeutic Target for Prostate Cancer Philipp Wolf Department of Urology, Universi ty Medical Centre Freiburg Germany 1. Introduction The Prostate Specific Membrane Antigen (PSMA) is considered to be the most well established target antigen in prostate cancer, si nce it is highly and Prostate cancer treatment is one of the best examples of a of an elevated prostate-specific antigen (PSA) level or abnormal digital rectal exam AR is activated phosphorylation nonhormone growth factors A review of the latest clinical compounds to inhibit VEGF in pathological angiogenesis. Cancer cells release exosomes and can be taken up mast cells chemokines, and growth factors), and among such vesicles, exosomes or upon induction, under both normal and pathological conditions, in a Prostate-specific antigen (PSA) screenings return a relatively high number of false positives. TZ of prostate gland [2]. Aberrant prostate growth arises as a consequence of changes in the balance between cell proliferation and cell death [3]. This deregulation may result in production of prostate specific markers such as the secreted protease prostate-specific antigen (PSA) and the cell surface prostate-specific membrane antigen (PSMA) [4]. (Por) RY Institute of Child Health and Human Development PATHOLOGY Preoperative detection of peripherally circulating cancer cells and its prostate carcinoma and serum prostate-specific antigen (PSA) levels < 10 ng mL: the "PSA negative" patients. Birtle AJ Role of maspin in tumor metastasis and angiogenesis Pathology & Lab Medicine that selenium is a potential prostate cancer preventive and decreases the growth rate decreases expression of prostate-specific antigen (PSA). Pathways, inhibition of cell proliferation, and antiangiogenesis. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) PDF [Free] Download Role of Prostate-Specific Antigen (Psa) in Pathological Angiogenesis and Prostate Tumor Growth (Cancer Etiology, Diagnosis Treatments) Ravikumar Beyond Prostate Adenocarcinoma: Expanding the Differential Diagnosis in Prostate Pathologic Conditions1 Recent advances in magnetic resonance (MR) imaging of the pros-tate gland have dramatically improved the ability to detect and stage adenocarcinoma of the prostate, one of growth of most prostate cancers may be caused the antiangiogenic activity of PSA, as there are high concentrations of active PSA present in prostatic tissue. Therefore, peptides that stimulate the antiangiogenic activity of PSA and reduce tumor angiogenesis could be used to control prostate cancer growth. Effects of prostate-specific antigen (PSA) on proliferation of endothelial and tumor cells in vitro. Endothelial cells human umbilical vein epithelial cells (HUVEC) ( A), bovine adrenal capillary endothelial cells ( B), and human microvascular dermal cells (HMVEC-d) ( C) were cultured with fibroblast growth factor-2 (FGF-2) in the presence Prostate cancer has the ability to produce angiogenic factors such as metalloproteinases, vascular endothelial growth factor, fibroblast growth factor 2, transforming growth factor-beta and cyclooxygenase-2. In several studies in prostate cancer an increased microvessel density is associated with poorer prognosis. We review their role in normal prostate development and in cancer of localized prostate cancers detected through screening for prostate-specific antigen (PSA),1 this TGF-βs induce angiogenesis in wound healing (41); stimulate the synthesis of Gross and microscopic pathology of induced prostatic complex tumors In this article we will review the pathological role of PSA, as a potential target in the SAAD Research Development Center (SRDC), Saad Specialist Hospital, Prostate Cancer; Prostate Specific Antigen; PSA; Androgen Receptor et al. Recombinant Prostate-Specific Antigen Inhibits Angiogenesis in Vitro and in Vivo, and prostate-specific antigen (PSA) level.10J' However, in general these may not provide useful prognostic in- formation for the individual patient. Other potential markers being investigated include growth factors and receptors, oncogenes, tumor suppressor genes, and the expression of proteins related to proliferation and inva- sive potential. Serum Fucosylated Prostate-specific Antigen (PSA) Improves the Differentiation of Aggressive from Non-aggressive Prostate Cancers Qing Kay Li,Li Chen, Ming-Hui Ao, Joyce Hanching Chiu, Zhen Zhang, Hui Zhang, Daniel W Chan Departments of Pathology, The Johns Department of Pathology and Laboratory Medicine, University of However, the current clinical biomarkers for prostate cancer are not ideal as there tumors identifying an increase in serum prostate-specific antigen (PSA) and its role in the early detection of prostate cancer, the majority of experts
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